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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA2
All Species:
19.7
Human Site:
S142
Identified Species:
43.33
UniProt:
O43464
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43464
NP_037379.1
458
48841
S142
V
P
S
P
P
P
A
S
P
R
S
Q
Y
N
F
Chimpanzee
Pan troglodytes
XP_508084
598
64926
S282
Q
G
Q
E
D
P
N
S
L
R
H
K
Y
N
F
Rhesus Macaque
Macaca mulatta
XP_001110803
458
48732
S142
V
P
G
P
P
P
A
S
P
R
S
Q
Y
N
F
Dog
Lupus familis
XP_532992
199
21668
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIY5
458
49330
S142
V
P
A
P
P
P
T
S
P
R
S
Q
Y
N
F
Rat
Rattus norvegicus
NP_001100069
458
49076
S142
V
P
A
P
P
P
T
S
P
R
S
Q
Y
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
S148
S
G
H
L
Q
S
S
S
P
R
Y
K
F
N
F
Frog
Xenopus laevis
NP_001088796
457
48812
S141
Q
G
Q
K
D
P
D
S
P
R
Y
K
Y
N
F
Zebra Danio
Brachydanio rerio
XP_001339411
294
31781
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
E121
A
D
S
V
V
Y
I
E
I
K
D
T
R
H
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
N141
D
S
S
S
K
P
S
N
G
Y
L
G
R
D
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.9
99.1
41.7
N.A.
84.9
87.3
N.A.
N.A.
40.9
41
43.6
N.A.
42.3
N.A.
N.A.
N.A.
Protein Similarity:
100
52.5
99.1
42.5
N.A.
89.3
91.4
N.A.
N.A.
59.4
59.1
54.3
N.A.
59.3
N.A.
N.A.
N.A.
P-Site Identity:
100
40
93.3
0
N.A.
86.6
86.6
N.A.
N.A.
33.3
46.6
0
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
46.6
93.3
0
N.A.
93.3
93.3
N.A.
N.A.
53.3
53.3
0
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
19
0
0
0
19
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
19
0
10
0
0
0
10
0
0
10
0
% D
% Glu:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
73
% F
% Gly:
0
28
10
0
0
0
0
0
10
0
0
10
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
10
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
10
0
0
0
0
10
0
28
0
0
0
% K
% Leu:
0
0
0
10
0
0
0
0
10
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
10
0
0
0
0
0
64
0
% N
% Pro:
0
37
0
37
37
64
0
0
55
0
0
0
0
0
0
% P
% Gln:
19
0
19
0
10
0
0
0
0
0
0
37
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
64
0
0
19
0
0
% R
% Ser:
10
10
28
10
0
10
19
64
0
0
37
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
19
0
0
0
0
10
0
0
10
% T
% Val:
37
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
10
19
0
55
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _